Package: Rcurvep
Type: Package
Title: Concentration-Response Data Analysis using Curvep
Version: 1.3.2
Authors@R: c(
        person("Jui-Hua", "Hsieh", email = "juihua.hsieh@gmail.com", role = c("aut", "cre"), comment = c(ORCID = "0000-0003-1620-1571")), 
        person("Alexander", "Sedykh", role = c("aut")),
        person("Fred", "Parham", role = c("ctb")),
        person("Yuhong", "Wang", role = c("ctb")),
        person("Tongan", "Zhao", role = c("aut")),
        person("Ruili", "Huang", role = c("ctb"))
        )
Description: An R interface for processing concentration-response
        datasets using Curvep, a response noise filtering algorithm.
        The algorithm was described in the publications (Sedykh A et
        al. (2011) <doi:10.1289/ehp.1002476> and Sedykh A (2016)
        <doi:10.1007/978-1-4939-6346-1_14>). Other parametric fitting
        approaches (e.g., Hill equation) are also adopted for ease of
        comparison. 3-parameter Hill equation from 'tcpl' package
        (Filer D et al., <doi:10.1093/bioinformatics/btw680>) and
        4-parameter Hill equation from Curve Class2 approach (Wang Y et
        al., <doi:10.2174/1875397301004010057>) are available. Also,
        methods for calculating the confidence interval around the
        activity metrics are also provided. The methods are based on
        the bootstrap approach to simulate the datasets (Hsieh J-H et
        al. <doi:10.1093/toxsci/kfy258>). The simulated datasets can be
        used to derive the baseline noise threshold in an assay
        endpoint. This threshold is critical in the toxicological
        studies to derive the point-of-departure (POD).
Language: en-US
BugReports: https://github.com/moggces/Rcurvep/issues
License: MIT + file LICENSE
URL: https://github.com/moggces/Rcurvep,
        https://moggces.github.io/Rcurvep/
Encoding: UTF-8
LazyData: true
Imports: dplyr (>= 1.0.0), tibble, magrittr, tidyselect, boot, tidyr,
        purrr, rlang, stringr, ggplot2, Rdpack, methods, rJava, furrr
RdMacros: Rdpack
Suggests: testthat, knitr, rmarkdown, tcpl, future
VignetteBuilder: knitr
SystemRequirements: Java
RoxygenNote: 7.2.3
Depends: R (>= 3.5)
Roxygen: list(markdown = TRUE)
Config/pak/sysreqs: make default-jdk libicu-dev
Repository: https://moggces.r-universe.dev
Date/Publication: 2025-05-30 13:28:32 UTC
RemoteUrl: https://github.com/moggces/rcurvep
RemoteRef: HEAD
RemoteSha: 7dd6963393731112109b6a8980539ccb6d0f5db7
NeedsCompilation: no
Packaged: 2026-07-03 22:47:40 UTC; root
Author: Jui-Hua Hsieh [aut, cre] (ORCID:
    <https://orcid.org/0000-0003-1620-1571>),
  Alexander Sedykh [aut],
  Fred Parham [ctb],
  Yuhong Wang [ctb],
  Tongan Zhao [aut],
  Ruili Huang [ctb]
Maintainer: Jui-Hua Hsieh <juihua.hsieh@gmail.com>